Dermafine-MD
Dermafine-MD is a micro active formula to help reduce the appearance of strech marks, wrinkles and age spots. Dermafine-MD gives you the ultimate repairing micro emulsion formula for rebuilding new skin and reducing the appearance of strech marks, wrinkles and age spots and even helps tighten and smooth your skin while it firms and nourishes it.

Dermafine-MD is a topical stretch mark cream with amazing technological anti-wrinkle properties. When applied to your face, it requires no painful peels,implants, or expensive injections, swelling, black and blue marks, puffiness and other complications that result from treatments and procedures such as Botox®.

Dermafine-MD retards the aging of cells and mimics Botox® treatments without the discomfort and expense!
Dermafine-MD's Micro Active formula penetrates the skin so effectively that you will see results within weeks if not days! It outperforms products with Retinol and Vitamin C and cost much less that other skin treatments such as Botox®! Dermafine-MD has an exclusive proprietary blend to increase its effectiveness.

To achieve these results Dermafine-MD uses a patented pentapeptide (25% more than Strivectin-SD) that has produced results unseen in the cosmetic industry. Together with a host of the industry's best anti-aging ingredients our blend targets major problem areas like sagging skin, skin discoloration, dryness and rough skin; not just wrinkles. And you can be sure to see these results immediately! Dermafine-MD has come to be known as the safe alternative to Botox^®, providing equal or better results without the risk.

Palmitoyl pentapeptide (a.k.a palmitoyl oligopeptide) is a new skin rejuvenation compound developed by the corporations Sederma SA and Proctor & Gamble. Lately, it has generated a lot of media buzz and has been included in a variety of pricey skin care formulas.

Chemically speaking, palmitoyl pentapeptide is a relatively small molecule (five amino acids linked together and attached to a fatty acid) structurally related to the precursor of collagen type I (a.k.a. procollagen type I). Researchers found that when added to the culture of fibroblasts (the key skin cells), palmitoyl pentapeptide stimulated the synthesis of the key constituents of the skin matrix: collagen, elastin and glucosamnoglycans. How exactly palmitoyl pentapeptide did that remains unclear, although a number of theories exist.

So far, clinical data are encouraging. One study demonstrated that palmitoyl pentapeptide was as effective as retinol in repairing sun-damaged skin but was devoid of side-effects. Most other studies showed at least some improvement in various objective and subjective measures of wrinkles. No side effects have been reported.

Palmitoyl pentapeptide may also be considered as a nonirritating fall back option for people who develop skin irritation in response to retinoids or alpha-hydroxy acids.

There is a large price variation between different palmitoyl pentapeptide products, although none are dirt-cheap. However, the price does not always reflect the concentration of the active ingredient. It might reflect prestige of the brand, advertising overhead, sophistication of packaging and so forth. Be wise. Make sure you are paying a fair price per unit of the pentapeptide.

Study:

The first study, conducted by Dr. Karl Lintner, with Sederma SA in Paris, France, and colleagues, examined the effects of palmitoyl pentapeptide 3 ppm versus retinol 700 ppm on photo-aged skin. This double-blind half-face study enrolled 16 healthy women. For four months, they applied a cream containing 700 ppm of retinol to the crow's feet area on one side of the face and the same base cream containing 3 ppm of palmitoyl pentapeptide to the other side of the face.

Patients applied the creams once daily for the first two months of the trial, then twice daily during months 3 and 4.

Significant improvement of the skin profile (determined by profilometry of wrinkle depth, length, volume, roughness) for patients using the peptide was observed at the two-month evaluation versus baseline with further improvement versus baseline after four months.

Dermatological scoring as well as image analysis confirmed a decrease in overall roughness and deep facial wrinkles with both treatments after four months. Although skin thickness increased by an average of 9 percent after four months for both treatments, the two-month data suggested that palmitoyl pentapeptide thickened the skin about 1.5 times faster than retinol.

Palmitoyl pentapeptide did not cause the inflammatory reactions frequently associated with retinol treatment.

Overall, the results suggest that palmitoyl pentapeptide is as effective as retinol at regenerating the skin but without the irritation that often occurs secondary to retinoid use, Dr. Lintner said.

Dr. Lintner and Dr. Jean Revuz, with Mondor Hospital in Paris and the current president of the WCD, presented the results of the second study, which examined the effects of palmitoyl pentapeptide 5 ppm on the structure of elastin and collagen IV in 49 women with photo-aged skin.

Over the course of the four-month, blinded study, the women who used 5 ppm of palmitoyl pentapeptide had substantial improvements in skin roughness, wrinkle volume, and wrinkle depth. Skin biopsies conducted on six patients indicated that palmitoyl pentapeptide triggered growth in elastin and collagen IV and enhanced the structure of elastin and collagen IV.

The researchers note that the peptide was not associated with any side effects and was "a safe and potent alternative to Retinoids in wrinkle repair."

Palmitoyl pentapeptide is a lipophilic modified peptide that is presently being investigated as an anti-aging ingredient. The peptide was developed by Sederma SA and is being tested by Sederma and Procter & Gamble Company in Cincinnati, Ohio.

Both studies were supported by Sederma SA.

General Guidelines:
• 2 to 4 Weeks - for mild or minor marks.
• 5 to 10 Weeks - for medium and darker marks.
• 11+ Weeks - for significant repair of severely damaged skin.

Dermafine-MD offers immediate results targeting the category of fine lines, wrinkles and crows feet and can remove 10-15 years from your complexion. The isolates in Dermafine-MD were shown in clinical studies to dramatically improve skin smoothness and decrease wrinkle depth as it increases collagen and elastin. It was shown to be even more effective than Retinol or Vitamin C in reducing fine facial lines and wrinkles while diminishing the signs of aging.

When comparing your options for anti-wrinkle creams Dermafine clearly comes out on top.  There are a number of creams on the market such as Strivectin-SD that cost $135 dollars but none offer the effectiveness and value that Dermafine provides.  This product is a powerful anti-wrinkle product which is safe and effective.  There is no need to undergo expensive and painful surgery or shots which offers risky and far from permanent results.   More importantly the continual use of Dermafine-MD will gradually rejuvenate the tone and texture of your skin to leave you long lasting effects. If you're still not convinced, read some of the testimonials:

"After using Dermafine-MD for about a week and a half I began to receive a lot of compliments from my friends.  They told me that I looked younger and more vibrant.  I definitely noticed an increase in the smoothness of my face and elasticity of my skin.  Now that I am using this formula I look and feel great!"

Sharon R.
Cincinatti, OH
 

"I'm 47 years old and I've always taken good care of my skin. Since I got married 28 years ago I've gone through dozens of different products. I was so disappointed when I started noticing that my skin color was uneven. The dermatologist prescribed a topical cream and medicine but three years later the improvement was small. I found your product online two months ago and it's amazing how much better my skin looks. Even my dermatologist is impressed! I haven't felt this good about myself in years! Thank you."

Terry A.
San Diego, CA

 "God I hate crow's feet!! They just wouldn't go away and they would make me look so old. I paid over $200 for a cream by ________ [name omitted due to trademark considerations] and at first it worked but they came back. I really thought I had tried everything. It's funny it was my mom who told me to try you guys. It really made a difference on her and I thought Dermafine had to work on me. Well it really did. I finally got rid of these ugly crow's feet for good! I've been using Dermafine for 4 months and so far so good."

Carol S.
Hoboken, NJ